Pickups Carry them with you", "The walls will harden over time. the lost item pool, white, black, Each time you take damage, you gain a damage up which lasts for the rest of the floor and turn a darker red colour each time, After taking 6 hits Bloody Lust doesn't give you any further damage increases, Damage given for each hit increases as follows: +0.5, +0.7, +0.9, +1.1, +1.3, +1.5, REPENTANCE - The damage increments have changed slightly, UNLOCK: Unlock this item by beating the Isaac boss with Samson, * item room, treasure room, item room pool, the lost item pool, starting, red, blood, drop, Upon use, reveals the map and drops either a soul heart or a random card/rune (50% chance for each), It reveals the location of the secret room, however it doesn't reveal the Super secret room, Has a chance to drop from playing a fortune machine. You must make it back through the path solving a few bomb puzzles while avoiding her, to get back to the regular floor. The rock wave deals 10 damage. Unlocked from the 'Once more with the feeling!' Azazel: Overrides Azazel's Brimstone. Pills with effects that can't necessarily 'double' are stronger, i.e. Tap the drop button to cycle between each one, Changes all card and rune drops into pills. "I'm seeing red" Items Counts as 1 of 3 poop items needed towards the Oh Crap transformation. Frozen enemies can be pushed into obstacles where they shatter on contact and fire ice shards around them. Brimstone can literally carry an otherwise doomed run to succes. Activates a random rune effect. I was incorrect. Counts as 1 of 3 mushroom items needed towards the Fun Guy transformation. Quality All you gotta do is Ctrl+F the real name of the item. The damage bonus is unaffected by both positive and negative damage multipliers. 5c pickups become 3c. Stat Down pills do nothing, and items like Experimental Treatment increase stats but don't reduce any, This effect works on items that apply negative stat modifiers, such as Soy Milk, This effect works for anything that gives temporary buffs, like Devil/Strength cards, or kill bonuses like Bloody Lust, If you somehow lose Rock Bottom, your stats will go back to normal, UNLOCK: Unlock this item by defeating the Boss Rush as Jacob & Esau, Bombs now explode with a random effect (e.g. Dinner = +0.5 tears, +0.2 shot speed. It gives you 2 seconds to pick it up again to re-heal, before it disappears, UNLOCK: Unlock this item by defeating Delirium as Tainted Magdalene, Whenever you deal damage to an enemy, has a chance to give the effect of one of Tainted ??? A blood clot is a bodily process that prevents excessive bleeding by forming a clot where the immense blood flow is, but can be harmful if it blocks an important passageway to a body organ. Caves 2: 1 Boss Item + 2 Soul Hearts, Depths 1: 4 Soul hearts. A familiar baby that fires tears which have a chance to freeze or petrify enemies, Counts as 1 of 3 familiar items needed towards the Conjoined transformation, When used, rerolls all items in the room into another random item from the current room's item pool, however the item also has a 30% chance to disappear, The chance associated with this item does NOT scale with your Luck stat - it's always 30%, In the game files this item is called 'Florians Dice', which is a reference to the Eternal update for the original Binding of Isaac game, which changed the D6 to act as this item does. Modes Share your thoughts, experiences, and stories behind the art. Item Tags Enemies include Candler, Lil' Haunt, Polty, Red Ghost, Wizoob and The Forsaken, The Haunt, The Heretic and The Rainmaker bosses. UNLOCK: Unlock this item by defeating Delirium in The Void floor with Isaac, A one time use active item that when used, will spawn 2 random item pedestals from the item pool associated with the current room (e.g. Modes Entity ID UNLOCK: Unlock this card by defeating Ultra Greedier mode as Tainted ??? From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac. The damage bonus is unaffected by both positive and negative damage multipliers. - Spawns the last pill you used. The Red Key item is required to access it, but it shows the direction to get there, UNLOCK: Unlock this item by defeating The Beast as Eve, Upon entering each new floor, if you have one red heart or less, another one is added, This effect works while moving up floors in the backwards path, This item has no effect for characters with non-red health i.e. shop item pool, x, paper, Makes all of Isaac's familiars stronger and bigger, Causes most familiars to deal double damage, Has no effect on most familiars that scale with Isaac's tear damage, * key master pool, key beggar pool, key judgement pool, shop room pool, shop item pool, red, heart, ?, Satan and The Lamb as Tainted Eve, A small clot friend will hug Isaac, following his exact movements (similar to how Jacob & Esau work) and shooting tears when he does, The clot can be moved around by collision with an object/wall, allowing you to re-position it, The clot's damage is roughly 1/3 of your tear damage, If it takes a few hits it will die, and respawn in the next room, UNLOCK: Unlock this trinket by defeating Mother as Tainted Eve, Spawns a random chest after completing a regular Challenge Room, Spawns a pedestal item after completing a boss Challenge Room, UNLOCK: Unlock this trinket by defeating Isaac, ?? This mechanic is very useful on Greed and Greedier modes, UNLOCK: Unlock this item by defeating Delirium in The Void floor with Keeper, *, orange, brown, yellow, gold, coin, cent, Upon use this item hurts Isaac without actually taking health away, allowing you to activate any items which trigger when taking damage without losing health, UNLOCK: Unlock this item by defeating Delirium on The Void floor with Eve, When used, this item permanently removes one of your red heart containers and gives you a flat +0.2 Damage Up, the Anemic effect (+1.5 Range Up + red creep trail) and a Cube of Meat, The Anemic effect will only last for the current room, but the Cube of Meat and Damage Up are both permanent, Only works for red hearts and has no effect when used if you only have soul/black hearts, Has no recharge time and can be used as often as you like, It is possible to generate multiple meatboys by stacking more than 4 Cubes of Meat, When used, this item gives you the effect of a random item for the rest of the room, Using this item multiple times in the same room will replace the previous item's effect with a new one, Certain items can be activated with this item which have unexpected effects and many items will do nothing, Items do not grant consumable drops which would normally occur when that item is picked up, Most flight-granting items have cosmetic effects only, and will not allow you to fly, Items that usually give HP up will not give extra health when gained from Metronome, UNLOCK: Unlock this item by defeating Greedier Mode with Eden, This dice allows you to press the Drop key to cycle between all possible dice effects and pick one to use, Charge time scales based on the chosen dice, updating every time you use it, Possible dice include: D1, D4, D6, D8, D10, D12, D20, D100. Anti-Gravity - Overrides Anti-Gravity. It appears as an alchemical symbol for sulfur. Additional copy of Monstro's Lung adds 3-5 more rings. *, blue, baby, grow, headless, golden chest pool, gold chest pool, Isaac's tears become coins and now have a 5% chance to drop pennies on the floor upon successfully hitting an enemy, Has a chance to drop when exploding a dead shopkeeper, A familiar blue fly that will follow Isaac's movement pattern but delayed by 1 second, Papa Fly will fire tears at nearby enemies that deal damage equal to Isaac's tear damage, A familiar baby that will follow your movement pattern on a 2 second delay, Tears that pass through the baby will double up and gain x1.33 speed boost, Isaac's normal bombs become pink and causes them to drop random pickups when they explode (e.g. Also the hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, silver, gray, grey, red, machine, Tears Down significantly (Tear delay * 2.1 + 3), Synergizes well with a lot of tear effects - e.g. The second piece drops after beating the Boss Rush as long as you are holding the first Broken Shovel piece (see previous 2 items for full details), After The Forgotten is unlocked, using it on the mound of dirt again just spawns a random type of chest, Each time you get hit, you drop a coin or two, REPENTANCE - No longer guaranteed to drop coins as The Keeper, UNLOCK: Unlock this item by beating Challenge #15 (Slow Roll), * , the lost item pool, cent, gold, water, wet, blue, While held, Isaac has a significantly higher chance to find drops when breaking poops, Lowers your spacebar item charge rate by 1, Cannot lower the charge of your spacebar item below 1 room, For example, you will now be able to use a 3 room charge item after 2 rooms instead, Does the teleport effect every time you use your current spacebar item, Can be used infinitely every room if you have Guppy's Paw and no red heart containers (Can be exploited to get to the boss room without clearing any other rooms), Higher chance for champion enemies while held, Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance, Does not attract other pickups like the full Magneto item does, Increases your chances to find an Angel Room instead of a Devil Room, Normally there is a 50%/50% chance of a Angel or Devil room with if a door spawns after the boss. Poison deals 5 damage initially and then 3.5, UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac, REPENTANCE - GB Bug is now a thrown projectile, activated by double tapping an attack button. Fort Myers, FL - Isaac James Blood, 46, of Brewer, Maine, and Fort Myers, Florida, passed away unexpectedly in his sleep on December 26, 2022. Based on the Steam Workshop mod created by Scayze and Ashkait, *, eyes, eyeball, bloody, white, red, googly googley, bank shot, Upon entering a room, a skull appears over a random enemy's head, Killing the marked enemy will cause the skull to move to a different enemy, If all enemies in the room are cleared in the order they are marked, Isaac gains a random reward from one of the following: Soul heart, Key, Pill, Bomb, Nickel, +0.2 Speed, +0.5 Range, +0.5 Tears, +1 Flat damage or +1 luck, Killing enemies in the wrong order will end the streak and deny you any extra rewards, Added as part of the Afterbirth+ Booster Pack #4. Unlock Method Counts as 1 of 3 fly items needed towards the Beelzebub transformation. Curse of the Lost), Black Candle removes the teleportation effect of Cursed Eye, +15% chance of a devil or angel room opening after the boss fight, UNLOCK: Unlock this item by donating 150 pennies to the Shop, * curse room pool, shop room pool, shop item pool, grey, gray, Gives Isaac high damage tears with a short range, Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does, Tear damage starts at triple (300%) and decreases over range to eventually be 0%, * item room, treasure room, item room pool, red, bloody, eyeball, If the total sum of all your health is at one heart after taking damage, the necronomicon effect will activate, dealing 40 damage to the entire room, REPENTANCE - Missing Page 2 now doubles all black heart and Necronomicon damage (to 80 instead of the usual 40), Item Pool: Devil Room, Demon Beggar, Secret Room, * demon beggar pool, demon judgement pool, devil beggar pool, secret room pool, devil pool, devil room pool, devil deal, the lost item pool, red, bloody, purple, paper, A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it, If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, Acquire Blood Clot 10 times. 68 . Can be used with Placebo to generate infinite batteries, Amnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop, Infested? UNLOCK: Unlock this item by defeating The Beast as ??? The effect is shown visually in 3 stages with the character's belly getting larger each time until it finally gives birth to a familiar. Touching the white flame temporarily turns you into The Lost, but allows you to walk through the mirror into a mirrored version of this floor. Supper = +0.5 tears, +1 luck. This item will modify drops from room clearing and champion enemies based on your current player state. Azazel has a chance to fire a beam with the damage bonus. ), REPENTANCE - The hit detection has been improved - Technology fires in a straight line, * item room, treasure room, item room pool, red, wire, white, eye, Isaac can now charge shots for more damage by holding down the fire button, At full charge, your tears do 4 times more damage, Tears fired at the minimum possible charge do roughly 1/3 of your normal damage, You can spam the fire button to rapid fire, however the overall damage per second will be low, * item room, treasure room, item room pool, brown, glass, beaker, white, * demon beggar pool, demon judgement pool, devil beggar pool, boss room pool, boss room item, Brimstone Blood laser barrage. Soul Hearts that are used to charge Spirit Shackles will not be added to your health as normal, UNLOCK: Unlock this item by defeating The Beast as The Forgotten, Taking damage reveals a random room on the minimap, and automatically opens certain doors in the current room. Each time you destroy a poop, this item will spawn 1-4 friendly Dip familiars that follow you, block shots and attack nearby enemies, Different poop types will spawn different types of Dip, each with their own effect, Golden poop dips can petrify enemies, turning them to gold for a few seconds. Picking up Brimstone will multiply Isaac's current damage by 3. Azazel- Azazel gets Brimstone, The Ludovico Technique, Cricket's Head, Demon Tail, and 1 red heart. Fire Dips burn enemies and leave a fire behind on death. blood clot es un aumento de dao parcial debido a que no solo una de dos lagrimas disparadas tengan mas dao este item es de la pool de habitacion del tesoro , bosses o por el item de polyp este item se aprobecha mas con el item de 20.20 ya que en este caso las probabilidades de que mas de una sola lagrima tenga ese aumento de dao This effect also works on Delirium if it is currently transformed into The Haunt while below half health, UNLOCK: Unlock this item by defeating Greedier mode as Bethany, Identified all pills on pickup, and converts them to their worse counterparts (e.g. in The Chest floor as The Forgotten, Item Pool: Item Room, Greed Mode item Room, When picked up, this item replaces all of your red heart containers with 6 Bone Hearts, Every time you lose a bone heart, lots of bones fire in all directions damaging any enemies hit and you gain a permanent +0.5 Tears Up, For the Lost and Keeper characters, this item simply gives a permanent Tears Up, UNLOCK: Unlock this item by defeating The Lamb in the Dark Room floor as The Forgotten, Obtained by beating the Basement 1 boss within 1 minute, then bombing the large shadow that appears in the middle of the starting room, While held, Mom's Foot will stomp on you from above twice every few seconds, and she will continue to stomp for as long as you hold this item, Using the Broken Shovel will stop Mom stomping you for the rest of the current room (or current wave if you're in the boss rush or challenge room), Beating the Boss Rush while holding this item will drop the second half of the Broken Shovel, which combine to create Mom's Shovel, which is used to unlock The Forgotten character, Dropping the Broken Shovel will cause it to disappear if you leave the room, NOTE: This item will not drop unless you have beaten The Lamb at least once, Added as part of the Afterbirth+ Booster Pack #5 and used in the quest to unlock The Forgotten character, Drops after beating the Boss Rush while holding the other half of the Broken Shovel (see previous item for more details), Combines with the first Broken Shovel piece to create Mom's Shovel (see next item for more details), When used, spawns a trapdoor that leads to the next floor, Unlocks The Forgotten character when used on a mound of dirt that appears in a room in The Dark Room floor, Obtained by combining the two Broken Shovel pieces. It's a 20% chance on first miss, 33% for a second miss and 50% for anything beyond that, Piercing shots work with this item and multiple hits with a single tear will each give a damage bonus, *, bullseye, target, grey, gray, black, red, circle, Isaac has a random chance to fire a Holy tear, which when it hits an enemy, will spawn a light beam on the same enemy, dealing damage, The beams from this item deal damage equal to 400% of your tear damage (4x damage multiplier for the beams only), The chance to fire a Holy tear is affected by your luck stat, maxing out at a 50% chance, Item Pool: Item Room, Greed Mode Item Room, Angel Room, A familiar host that sits on Isaac's head and has a 20% chance to block enemy shots, When a shot is blocked, Host Hat will fire 3 bullets back at the enemy, Causes you to become immune to explosions, but doesn't protect against stomps or shockwaves, Causes your shops to instantly restock their items when you buy them, New items generated by Restock are from the shop item pool, The cost increases exponentially every time you purchase an item. *, stone, rock, grey, gray, white, dice, pip, broken, die, While held this trinket causes all pickups and enemies to move slowly towards you, Will also attract the Mom's Foot and Ultra Greed door entities, *, white, grey, gray, pill, medicine, drug, Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them, This trinket can be used to open the door to Mausoleum in Depths II, Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies, Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it, *, green, bogey, snot, ocarina, bobs bladder, bob bladder, Gives a +6.66% chance of a getting a small battery after clearing a room, Gives a +2.0% chance for pickups to be small batteries, Gives a +5.0% chance to add an extra charge to your active item after clearing a room, *, metal, grey, gray, silver, pill, cross, Exploding bombs now have a chance to drop another bomb that you can pick up, Higher chance to find crawl spaces when exploding rocks, UNLOCK: Unlock this trinket by beating Challenge #27 (Brains), *, toe, finger, thumb, grey, gray, black, red, yellow, Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game. Modes The most common signs are crushing chest pain and difficulty breathing. The spear cannot be thrown like Mom's Knife but deals damage while it is in contact with an enemy, *, grey, silver, sword, dagger, blade, knife, Tears now have a random chance to become sticky bombs, which will attach to enemies and explode after a few seconds, The bomb explosion deals your tear damage + 60, REPENTANCE - Explosivo tears now deal damage upon impact, When picked up, drops between 1-6 random pickups on the floor, Causes all item pedestals to be chosen from a random item pool instead of the pre-defined ones which normally exist, Fixed item drops won't be replaced - e.g. ?, Satan and The Lamb as Tainted Judas, Changes Devil Room layouts. Picking up Brimstone will multiply Isaac's current damage by 3. For Items it increases by 2 coins * the number of purchases. Any Tarot card or rune on the floor or current held when picking this item up will change into a pill, Dice Shard counts as a card and will be converted, UNLOCK: Unlock this item by picking up 2 of the following items: Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball, * shop room pool, shop item pool, brown, purple, * boss room pool, boss room item, red, wedge, purple, triangle, The above stats only apply to tears fired from Isaac's left eye or with a 50% chance if you have an item which causes you to fire from a single source only, * boss room pool, boss room item, red, blob, circle, spot, * boss room pool, boss room item, grey, gray, Enemies touching placed bombs take 16 damage, Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies, REPENTANCE - Hot Bombs now have greatly increased contact damage (increased from 1 to 16), and passively grants Isaac immunity to fire, * item room, treasure room, item room pool, fire, orange, flame, face, Isaac's tears now set enemies on fire, leaving a damage over time effect that does 4 or 6 damage per tick, There is a chance that tears that hit enemies will explode, leaving a small fire on the floor that damages enemies, Exploding tears deal damage * 2 + 22 per tick, The chance for tears to explode is affected by your luck stat and at +13 Luck it will activate every time, * item room, treasure room, item room pool, fire, flame, orange, back, ball, burning, When picked up, and at the start of each floor this rerolls all your current items, giving you a new item to replace each of the ones you had, Also rerolls all your stats at the same time, giving a random flat modifier that changes each time, Doesn't affect important items such as Polaroid, Negative and Key Pieces, UNLOCK: Unlock this item by beating Boss Rush with Lazarus, * secret room pool, mondrian, painting, yellow, blue, red, white, Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac, The chance to fear enemies is affected by your luck stat and at +20 Luck it will activate every time, An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool), * devil pool, devil room pool, devil deal, grey, gray, fist, glow, Immunity to all floor curses (e.g. It increases by 2 coins isaac blood clot brimstone the number of purchases do is Ctrl+F the real name of the.! 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