However, more direct research is warranted in this regard. So, consult a doctor to understand about its long term usage. jaundice. Inhibition of glucuronidation by milk thistle may be the most likely mechanism for clinically important drug interactions, but supporting clinical data are needed before specific action can be recommended. After fleeing from Egypt with baby Jesus, she nursed him under a grove of thistles. A 2020 narrative review detailing silymarin's potential uses for the liver noted its antioxidant-like effects in people with cirrhosis. High cholesterol can lead to problems with heart health and increase a persons chance of stroke. Bunchorntavakul C, Wootthananont T, Atsawarungruangkit A. Phytomedicine. Milk thistle may not be safe for everyone. 2016;5147468. doi:10.1155/2016/5147468. If left untreated, anaphylaxis can lead to shock, coma, cardiac or respiratory failure, or even death. Rev Diabet Stud. By Brittany Lubeck, RD People with diabetes should use caution. Milk thistle may help to promote healthy skin. List Milk Thistle Capsule side effects by likelihood and severity. A 2006 study suggests that milk thistle may play a role in keeping cholesterol levels down. Finally, those with hormone-sensitive conditions, including certain cancers, may need to avoid using milk thistle. Check out our. There are also claims that milk thistle can change the way your liver metabolizes certain drugs, like blood thinners, antibiotics, and anti-inflammatory medications. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. Cochrane Database Syst Rev. Milk thistle seeds contain silymarin. Other potential benefits include . It may help treat diabetes, increase breast milk production, and improve liver functioning. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. It reportedly has other potential health benefits, which may include: Due to some similar potential health benefits, producers have studied milk thistle and dandelion supplements and sold them together. Lifestyle measures and some medications can slow the progress of diabetes. Effect of silymarin on biochemical indicators in patients with liver disease: systematic review with meta-analysis. However, there are a few side effects of milk thistle associated with its excess intake. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. The terms "milk thistle" and "silymarin" are often used interchangeably. Can Apoaequorin Really Improve Your Memory? 2012;308(3):274-282. doi:10.1001/jama.2012.8265. The name milk thistle is associated with the legend of Mother Mary. You can buy milk thistle online in the supplement form. Deng JW, Shon JH, Shin HJ, et al. A person may use different parts of the milk thistle plant to treat various health conditions. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. 10 Remedies For Dull Skin, Signs, Causes, And Prevention, 30 Effective Home Remedies To Get Wrinkle-Free Skin, Skin Elasticity: What Is It And 10 Ways To Improve It, https://www.ncbi.nlm.nih.gov/books/NBK11896/, https://nccih.nih.gov/health/milkthistle/ataglance.htm, https://www.ncbi.nlm.nih.gov/books/NBK541075/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538855/, https://www.frontiersin.org/articles/10.3389/fonc.2019.01356/full, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4164972/, https://journals.sagepub.com/doi/pdf/10.1177/1534735407301942, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116427/, https://www.ncbi.nlm.nih.gov/pubmed/25396404, https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/silybum-marianum, https://www.karger.com/Article/Fulltext/334488, https://www.ncbi.nlm.nih.gov/books/NBK65780/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586829/, https://pubmed.ncbi.nlm.nih.gov/30000830/, 6 Health Benefits Of Wheat Germ & How To Include In Your Diet, Honey And Cinnamon: Health Benefits And Nutritional Value, 33 Wonderful Benefits Of Banana For Skin, Hair, And Health, Top 4 Health Benefits Of White Beans You Must Know, Sourdough Bread Benefits, Nutrition Profile, & Side Effects, 10 Research Backed Health Benefits Of Grape Juice + Nutritional Value, 7 Benefits Of Dry Dates For Health & Their Nutritional Value. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. Silymarin, a Promising Pharmacological Agent for Treatment of Diseases, Iranian University of Medical Sciences, US National Library of Medicine, National Institutes of Health. Consult your doctor for more information if you have either of these serious conditions.Some herbal/dietary supplement products have been found to contain possibly harmful impurities/additives. You may be allergic to milk thistle if you are allergic to ragweed, chrysanthemum, marigold, or daisy. Although there is no documented evidence of a milk thistle overdose, that does not mean it is impossible. Occasionally, people report various digestive side effects. People commonly take milk thistle by mouth for diabetes. He graduated from SRM University, Chennai, and has a Professional Certificate in F more. One of milk thistle's traditional uses is easing indigestion. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. J Diabetes Res. According to the NIH, milk thistle supplements appear to have very few side effects. Milk thistle has a range of potential health benefits due to its active ingredient, silymarin, which is an antioxidant. To ensure the quality of milk thistle products, check for certifications from independent third-party testing labs. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Before using this product, tell your doctor or pharmacist of all the products you use. Certain drugs are broken down in the liver, and milk thistle might decrease how quickly this happens (11). Milk thistle may cause an allergic reaction in those with allergies to plants in the same family, like ragweed, chrysanthemum, marigold, and daisy. Cathy Wong is a nutritionist and wellness expert. Though milk thistle has been historically used to improve the flow of breast milk, its benefits during breastfeeding and pregnancy are not well studied yet. 2015;22(2):290-6. doi:10.1016/j.phymed.2014.12.010. Some, but not all, milk thistle supplements are vegan. Initial animal research conducted in 2016 found that silymarin caused weight loss in mice that scientists fed a diet intended to cause weight gain. Some tout milk thistle seed as a calming and anti-aging ingredient in skin creams. A double-blind controlled study. Call your doctor for medical advice about side effects. A.D.A.M. Keep all medications and herbal products away from children and pets. Although research is still emerging, milk thistle may be beneficial for conditions relating to the liver and gallbladder. Call your doctor for medical advice about side effects. Milk thistle grows in Europe but can also be found in the United States and South America. The plants are native to the Mediterranean regions of Europe, North Africa, and the Middle East.One species has been introduced elsewhere, including in North America. Researchers must carry out more studies on humans to confirm the effects of milk thistle on cognition. Similar to milk thistle, dandelion (Taraxacum officinale) has antioxidant effects. 2015;22(2):290-296. doi:10.1016/j.phymed.2014.12.010. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Of the total drug interactions, 3 are moderate, and 1 is minor. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. You may report side effects to FDA at 1-800-FDA-1088. Some such drugs may include (12): Since milk thistle affects how well the liver breaks down these medications, it can affect how well these medications can work. Regardless, interactions are still possible. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. StyleCraze provides content of general nature that is designed for informational purposes only. Scientists think this creates a detoxifying effect, which is why milk thistle may be beneficial for liver problems. 2016;2016:5147468. doi:10.1155/2016/5147468. Mothers who used milk thistle to boost their milk production reported unwanted weight gain along with irritability and nausea (16). The extract of the seeds of milk thistle contains a number of substances, collectively called silymarin. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Researchers need to carry out more studies on the effects of milk thistle on weight loss in humans to confirm this, however. The common name, milk thistle, is derived from the "milky white" veins on the leaves, which, when broken open, yield a milky sap. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. This is not a complete list of possible side effects. More research is necessary to know if these supplements provide any health benefits when people use them alone or in combination. The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. Medical research on milk thistle and liver health has led to mixed results. You may report side effects to FDA at 1-800-FDA-1088. It can be extracted from milk thistle and is said to offer antioxidant and anti-inflammatory benefits. You can learn more about how we ensure our content is accurate and current by reading our. Ebrahimpour koujan S, Gargari BP, Mobasseri M, Valizadeh H, Asghari-jafarabadi M. Effects of Silybum marianum (L.) Gaertn. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). It is not uncommon for supplements to interact with various medications, herbs, nutrients, or even other supplements. Effects of Silybum marianum (L.) Gaertn. Milk thistle side effects (more detail) Milk thistle contains a chemical called silymarin, which can decrease blood sugar levels (10). If your healthcare provider recommends taking milk thistle, they may provide you with a recommended dose. Does milk thistle cause any side effects? It is unknown if this product passes into breast milk. He has been in the digital media field for over eight years. Historically, people have used milk thistle for liver disorders and gallbladder problems. Available for Android and iOS devices. Does Milk Thistle Capsule interact with other drugs you are taking? It is also unknown whether milk thistle is safe for children. Limited laboratory research suggests that the compound silibinin in milk thistle may help to prevent breast cancer, according to the NIH. A 2012 study found that silymarin helped to protect against inflammation in the airways of mice with allergic asthma. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Of thistles any medical emergency or for the skin, hair, and has Professional. 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