Because this action has been exempted from review under Executive Order 12866, this action is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997), nor is it considered a regulatory action under Executive Order 13771, entitled Reducing Regulations and Controlling Regulatory Costs (82 FR 9339, February 3, 2017). on Application of Palisade or Palisade plus Tilt increased grain yield at Chickasha and had no effect on grain yield at Stillwater or Perkins. menu. We as supplier shall not be held liable for any damage resulting from handling or from contact with the above product. The Public Reading Room is open from 8:30 a.m. to 4:30 p.m., Monday through Friday, excluding legal holidays. documents in the last year, 37 Fluid, Electrolyte, and Acid-base Balance, View all products of Market Price & Insight, Trade Alert - Delivering the latest product trends and industry news straight to your inbox. How doesTrinexapac-ethyl work? Wheat lodging is not generally a widespread problem in Oklahoma, but it does occur. Remove contaminated clothes. The Public Inspection page may also This information is not part of the official Federal Register document. Wheat plant heightas affected by plant growth regulators in 2013, Wheat plant height as affected by plant growth regulator in 2014. documents in the last year, 87 [Reserved], [FR Doc. Uncertainty/safety factors (U/SF) are used in conjunction with the POD to calculate a safe exposure levelgenerally referred to as a population-adjusted dose (PAD) or a reference dose (RfD)and a safe margin of exposure (MOE). In 2013 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. What are the uses of Trinexapac-ethyl ? Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. do not apply. Adequate enforcement methodology (Method GRM020.01A, which utilizes high performance liquid chromatography with triple-quadrupole mass spectrometry (LC-MS/MS)) is available to enforce the tolerance expression. Therefore, for the reasons stated in the preamble, EPA amends 40 CFR chapter I as follows: 1. I provided 2013 results in a blog post last year, and this post provides an update including our 2014 findings. Employees. Based on current evidence, plant growth regulators in Oklahoma are best kept on acres with high (> 80 bu/ac) yield potential that may have greater propensity for lodging due to variety or fertility. This action does not involve any technical standards that would require Agency consideration of voluntary consensus standards pursuant to section 12(d) of the National Technology Transfer and Advancement Act (NTTAA) (15 U.S.C. The numbers in the figure do not account for harvest losses, which can exceed losses associated with lower photosynthetic capacity shown in the figure. EPA considers the international maximum residue limits (MRLs) established by the Codex Alimentarius Commission (Codex), as required by FFDCA section 408(b)(4). Though dose-related neuropathology of the brain was observed in the dog, EPA has concluded that there is no need for a developmental neurotoxicity (DNT) study or additional UFs to account for neurotoxicity for the following reasons: Although subchronic inhalation data on trinexapac-ethyl are not available and an oral study was selected for inhalation risk assessment, the selected points of departure are considered adequately protective for all exposed populations. for better understanding how a document is structured but Syngenta Crop Protection, Inc. requested these tolerances under the Federal Food, Drug, and Cosmetic Act (FFDCA). documents in the last year, by the Centers for Medicare & Medicaid Services on Based upon review of the data supporting the petition, EPA has revised most of the proposed tolerance levels, added tolerances for hog fat and meat, and deleted the proposed tolerance for cattle kidney. 1. For complete information about, and access to, our official publications Trinexapac-ethyl. Response to Syngenta's Rebuttal to Plant-back Interval Trinexapac-ethyl End Use Label (Palisade 2EC) and Acceptance Trinexapac-ethyl End Use Label (Palisade EC) and Acceptance Trinexapac-ethyl Technical Label and Letter of Acceptance. About the Federal Register Furthermore, similar lesions were not observed in the rat or mouse following subchronic or chronic dietary exposure, and there was no other evidence in any species tested to indicate a neurotoxicity potential. The mutagenicity database is also complete, with no evidence of mutagenicity. Separated from food and feedstuffs. . document.write(" Hide\u00A0index<\/span><\/a>\u00A0|") Avoid contact with skin and eyes. establishing the XML-based Federal Register as an ACFR-sanctioned on FederalRegister.gov S-4400, One Potomac Yard (South Bldg. Acute risk. Recommendations may change as further research is conducted and new information is obtained. 2012-4984 Filed 3-1-12; 8:45 am], updated on 4:15 PM on Tuesday, February 28, 2023, updated on 8:45 AM on Tuesday, February 28, 2023, 104 documents Revising the existing entries in the table for Sugarcane, cane and Sugarcane, molasses. Trinexapac-ethyl is classified as Not likely to be carcinogenic to humans. The combined chronic toxicity/carcinogenicity study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans. headings within the legal text of Federal Register documents. Our results are consistent with other wheat plant growth regulator research, which has reported similar variation in response among sites and years. Provision to contain effluent from fire extinguishing. Superintendents across the Southeast are looking for ways to maintain their golf course with fewer staff members. Any trinexapac-ethyl that hits the soil is lost. We included an untreated check and ALL plots, including the check, received 10.5 oz/ac of Quilt Xcel at Feekes GS 10.5 (heading). of the SUPPLEMENTARY INFORMATION). of the SUPPLEMENTARY INFORMATION). Cancer. There are no tolerances currently established for trinexapac-ethyl. These setups such as with a boomless nozzle require higher actual product rates. Combustible. In this Issue, Documents 2. documents in the last year, by the Federal Highway Administration Determination of safety. In laboratory experiments with annual . This PDF is Bispyribac-sodium selectively controls annual bluegrass in cool-season turf but efficacy may be influenced by management practices, such as plant growth regulator use. Potentially affected entities may include: You may access a frequently updated electronic version of EPA's tolerance regulations at 40 CFR part 180 through the Government Publishing Office's e-CFR site at http://www.ecfr.gov/cgi-bin/text-idx?&c=ecfr&tpl=/ecfrbrowse/Title40/40tab_02.tpl. EPA may establish a tolerance that is different from a Codex MRL; however, FFDCA section 408(b)(4) requires that EPA explain the reasons for departing from the Codex level. Trinexapac-ethyl is a plant growth regulator that inhibits the formation of gibberellic acid and is used as an anti-lodging agent. Chronic oral toxicity studydog. Therefore, based on the risk assessments and information described above, EPA concludes there is a reasonable certainty that no harm will result to the general population or to infants and children from aggregate exposure to trinexapac-ethyl residues. In applying this provision, EPA either retains the default value of 10X, or uses a different additional safety factor when reliable data available to EPA support the choice of a different factor. The acute dietary exposure was only estimated for females 13 to 49 years old based on an in utero effect (decrease in mean number of fetuses/litter and an increase in post-implantation loss) identified in the rabbit developmental study. ), 2777 S. Crystal Dr., Arlington, VA. documents in the last year, 1408 For more information on the general principles EPA uses in risk characterization and a complete description of the risk assessment process, see http://www.epa.gov/pesticides/factsheets/riskassess.htm. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. This action directly regulates growers, food processors, food handlers, and food retailers, not States or Tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of FFDCA section 408(n)(4). The Codex Alimentarius is a joint U.N. Food and Agriculture Organization/World Health Organization food standards program, and it is recognized as an international food safety standards-setting organization in trade agreements to which the United States is a party. This feature is not available for this document. This final rule directly regulates growers, food processors, food handlers, and food retailers, not States or tribes, nor does this action alter the relationships or distribution of power and responsibilities established by Congress in the preemption provisions of section 408(n)(4) of FFDCA. the material on FederalRegister.gov is accurately displayed, consistent with The trinexapac-ethyl changes the size of the corn p lants, enabling new spatial arrangements. Hazards Identification Hazard Statement Not a hazardous chemical according to the criteria of Safe Work Australia (SWA). The toxicology database for trinexapac-ethyl is largely complete, with the exception of a subchronic neurotoxicity study, which is a new data requirement under 40 CFR part 158 for registration of a pesticide (food and non-food uses OPPTS 870.6200b). In the mouse, there was no evidence of carcinogenicity. These markup elements allow the user to see how the document follows the documents in the last year, 474 documents in the last year, 24 The telephone number for the Public Reading Room is (202) 566-1744, and the telephone number for the OPP Docket is (703) 305-5805. You may be potentially affected by this action if you are an agricultural producer, food manufacturer, or pesticide manufacturer. documents in the last year, by the Employment and Training Administration To access the OCSPP test guidelines referenced in this document electronically, please go to http://www.epa.gov/ocspp and select Test Methods and Guidelines.. Pursuant to the Congressional Review Act (5 U.S.C. We conducted the trial at Stillwater (Irr), Perkins (Irr), and Chickasha (Non-Irr). This table of contents is a navigational tool, processed from the trinexapac-ethyl is used as a foliar spray, post-emergence to control the growth on various grass species and crops. Quality CAS 95266-40-3 Trinexapac-ethyl - find quality Agrochemical Pesticide, Organic Acid & Agrochemical Pesticide from Hebei Luantong trade.co of China Suppliers - 168640825. . B. Developmental rabbit study. In 2013 and 2014 we evaluated the plant growth regulator trinexapac-ethyl, which is sold under the trade name Palisade. However, the existing legal framework provided by section 408 of FFDCA contemplates that tolerances greater than zero may be set when persons seeking such tolerances or exemptions have demonstrated that the pesticide meets the safety standard imposed by that statute. Similarly, EPA does not believe that the non-dietary residential exposures are underestimated because they are based on the conservative assumptions of EPA's Draft Standard Operating Procedures (SOPs) for Residential Exposure Assessments (December 1997), and updates contained in the Science Advisory Council Policy 12 (February 2001) as well as the uses specified in the proposed labels. Human Health Risk Assessment for the Petition to Amend the Pre-Harvest Intervals on Sugarcane. dated July 13, 2020 in the docket ID number EPA-HQ-OPP-2020-0046. Information not marked confidential pursuant to 40 CFR part 2 may be disclosed publicly by EPA without prior notice. In terms of revenue, the global top. Tolerances are established for residues of the plant growth inhibitor, trinexapac-ethyl, including its metabolites and degradates, in or on the commodities in the table below. Trinexapac-ethyl EPA registers pesticides under Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA). These markup elements allow the user to see how the document follows the Lose the iron and calcium. It is interesting to note that the Palisade treatment increased grain yield at Perkins in 2013 even though the plots lodged at comparable levels as the non treated check. The documents posted on this site are XML renditions of published Federal the official SGML-based PDF version on govinfo.gov, those relying on it for A harmful contamination of the air will not or will only very slowly be reached on evaporation of this substance at 20C; on spraying or dispersing, however, much faster. The reasons for these changes are explained in Unit IV.D. LOAEL = 357 mg/kg/day, based on elevated serum cholesterol values in females, mucoid feces in females and bloody feces in both sexes, and minimal, focal vacuolation of the dorsal medial hippocampus and/or lateral midbrain in both sexes. The article can be found at the link below: Anderson, N.P., D.P. 0 For chronic dietary risk assessment, the water concentration of value 1.56 ppb was used to assess the contribution to drinking water. Process Trigger: First Food Use Registration Review Case: TRINEXAPAC-ETHYL , Case #7228: Substance Information . documents in the last year, 36 Chronic dietary risks are below the Agency's level of concern: 6.6% of the chronic population adjusted dose (cPAD) for children 1 to 2 years old, the population group receiving the greatest exposure. Trinexapac-ethyl; tolerances for residues. Substance Name: Trinexapac-ethyl [ISO] RN: 95266-40-3 UNII: Q89W563T9J InChIKey: RVKCCVTVZORVGD-QXMHVHEDSA-N. Trinexapac-ethyl (TE) is well-known as an anti-gibberellin plant growth regulator [1] . Specific information on the studies received and the nature of the adverse effects caused by trinexapac-ethyl as well as the no-observed-adverse-effect-level and the lowest-observed-adverse-effect-level from the toxicity studies can be found at http://www.regulations.gov in the document, Trinexapac-ethyl: Human Health Risk Assessment for the Section 3 Registration Action on Cereal Grains, Sugarcane, and Grasses Grown for Seed p. 48 in docket ID number EPA-HQ-OPP-2010-0524. Trade Capacity. Based on the residential use patterns for trinexapac-ethyl, chronic residential exposure to residues is not expected. Compliance with the tolerance levels specified below is to be determined by measuring only the free and conjugated forms of both trinexapac-ethyl, ethyl 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylate and trinexapac, 4-(cyclopropylhydroxymethylene)-3,5-dioxocyclohexanecarboxylic acid, calculated as the stoichiometric equivalent of trinexapac-ethyl, in or on the commodity. corresponding official PDF file on govinfo.gov. For the purposes of this tolerance action, therefore, EPA has assumed that trinexapac-ethyl does not have a common mechanism of toxicity with other substances. This regulation is effective November 4, 2020. If these high yield potential acres are being sprayed with a growth regulator at GS 7, the addition of a foliar fungicide might be prudent if it can be included at a relatively low cost. [FR Doc. For linear cancer risks, EPA calculates the lifetime probability of acquiring cancer given the estimated aggregate exposure. Federal Register issue. establishing the XML-based Federal Register as an ACFR-sanctioned Many of the proposed tolerances are different from the tolerances being set by EPA. documents in the last year, by the Federal Communications Commission headings within the legal text of Federal Register documents. for better understanding how a document is structured but . EPA has sufficient data to assess the hazards of and to make a determination on aggregate exposure for trinexapac-ethyl including exposure resulting from the tolerances established by this action. Bethany Benbow, Registration Division (7505P), Office of Pesticide Programs, Environmental Protection Agency, 1200 Pennsylvania Ave. hbbd``b`Z$@`N{!:X "Dh,T&Fv B EPA is setting different levels than were proposed based on EPA's analysis of the field trial data using the Organization for Economic Cooperation and Development tolerance calculation procedures. Each document posted on the site includes a link to the . Palisade did not affect lodging at Perkins in 2013. They were not associated with other neuropathological findings or overt neurological signs so their biological significance is unknown. ), do not apply. We conducted the trial at Stillwater (Irr), Perkins (Irr), and Chickasha (Non-Irr). 2. The President of the United States issues other types of documents, including but not limited to; memoranda, notices, determinations, letters, messages, and orders. New Documents Register (ACFR) issues a regulation granting it official legal status. In the mouse, there was no evidence of carcinogenicity. 801 et seq. Please review additional information about the docket available at http://www.epa.gov/dockets. tradeKorea is a online B2B trade website offers you matching services to connect buyers and suppliers. Research has shown that increasing the soil water content from 17 to 26% reduced the force required for anchorage failure by 33%, and as little as 0.25 inches of water plus 11 mph winds were enough to cause lodging. that agencies use to create their documents. Can you pronounce this word better Trinexapac (free acid) 112ZF04MPX Cyclohexanecarboxylic acid, 4- (cyclopropylcarbonyl)-3,5-dioxo- Cyclohexanecarboxylic acid, 4- (cyclopropylhydroxymethylene)-3,5-dioxo- Trinexapac acid 4- (Cyclopropyl (hydroxy)methylene)-3,5-dioxocyclohexanecarboxylic acid UNII-112ZF04MPX Trinexapac [ISO] SCHEMBL125835 CHEBI:83454 DTXSID90559517 DTXSID501019900 Use spark-proof tools and explosion-proof equipment. In addition, this action does not impose any enforceable duty or contain any unfunded mandate as described under Title II of the Unfunded Mandates Reform Act (UMRA) (2 U.S.C. documents in the last year, 11 ABSTRACT. Comments were received on the notice of filing. .. 4-[cyclopropyl(hydroxy)methylidene]-3,5-dioxocyclohexane-1-carboxylic acid, Growth Retardant Effects Caused By Interfering With Gibberellin Biosynthesis, Plant Growth Regulators (Unclassified Plant Growth Regulators) [1]. Although there is evidence of susceptibility in the rat and rabbit developmental studies and in the rat reproduction study, EPA's concern for these effects is low, and there are no residual uncertainties since the effects only occurred at the highest doses tested (360-1,200 mg/kg/day), for each study, and there were clearly identified NOAELs (60-593 mg/kg/day) for each fetal/offspring effect. A quantitative and confirmatory method for the analysis of trinexapac (free acid metabolite of trinexapac-ethyl) in wheat is described. The suppliers of 39 Trinexapac-ethyl on the search result are been verified by the accurate information of each one. As to residue levels in food, EPA assumed that residues are present in all commodities at the tolerance level and that 100% of commodities with tolerances are treated with trinexapac-ethyl. Evidence of increased qualitative and quantitative susceptibility to offspring exists at or above the limit dose of the developmental and reproduction studies. This chemical is managed as part of a group or group(s). documents in the last year, 11 Most requests are made by state . EPA has evaluated the available toxicity data and considered its validity, completeness, and reliability as well as the relationship of the results of the studies to human risk. Because this final rule has been exempted from review under Executive Order 12866, this final rule is not subject to Executive Order 13211, entitled Actions Concerning Regulations That Significantly Affect Energy Supply, Distribution, or Use (66 FR 28355, May 22, 2001) or Executive Order 13045, entitled Protection of Children from Environmental Health Risks and Safety Risks (62 FR 19885, April 23, 1997). documents in the last year, 37 Ensure adequate ventilation. has no substantive legal effect. Elements allow the user to see how the document follows the Lose iron... Does occur were not associated with other neuropathological findings or overt neurological signs so their biological significance unknown... Study in the rat did not demonstrate an increase in any tumor type that would be relevant to humans the... 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